During the trial https://www.jewelryntjb9.top/, the highest tolerated dose of liraglutide or placebo was used.Since the participants had inadequate glycaemic control at inclusion (HbA1c 58 mmol/mol (7.5%)), no general reduction in insulin doses were recommended when initiating or titrating liraglutide or placebo.11 Reductions in insulin were only considered in participants with normal or close to normal glucose levels at fasting or before meals (If glucose levels were not on target after titrating liraglutide or placebo we recommended increasing insulin doses to original levels. After the titration phase of liraglutide and placebo, we advised the participants to adjust their insulin doses throughout the study as performed daily before enrolling in the trial. The participants were advised to measure three or four glucose values each day before meals and at bedtime according to clinical guidelines for potentially adjusting insulin doses, diet, or physical activity.After randomisation, follow up visits took place at weeks 6, 12, 18, and 24.
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